4-bromo-6-methyl-1-tosyl-1H-pyrrolo[2,3-c]pyridin-7(6H)-one synthesis
- Product Name:4-bromo-6-methyl-1-tosyl-1H-pyrrolo[2,3-c]pyridin-7(6H)-one
- CAS Number:1445993-87-2
- Molecular formula:C15H13BrN2O3S
- Molecular Weight:381.24
![4-bromo-1-tosyl-1H-pyrrolo[2,3-c]pyridin-7(6H)-one](/CAS/20180629/GIF/1445993-86-1.gif)
1445993-86-1
25 suppliers
inquiry
74-88-4
349 suppliers
$15.00/10g
1445993-87-2
58 suppliers
$445.00/1g
Yield:1445993-87-2 96%
Reaction Conditions:
Stage #1:4-bromo-1-[(4-methylphenyl)sulfonyl]-1,6-dihydro-7H-pyrrolo[2,3-c]pyridin-7-one with sodium hydride in N,N-dimethyl-formamide;mineral oil for 0.5 h;Inert atmosphere;
Stage #2:methyl iodide in N,N-dimethyl-formamide;mineral oil at 20; for 3 h;Inert atmosphere;
Steps:
1; 1e 4-bromo-6-methyl-1-tosyl-1H-pyrrolo[2,3-c]pyridin-7(6H)-one
Sodium hydride (0.875 g, 36.5 mmol, 1.46 g of a 60% in oil dispersion) was added to a stirring solution of Example Id (11.2 g, 30.4 mmol) in dimethylformamide (217 mL) under nitrogen. After 30 minutes, iodomethane (2.27 mL, 36.5 mmol) was added and the solution was stirred at room temperature for 3 h. Upon addition of water (250 mL) a precipitate formed. The precipitate was collected by vacuum filtration, rinsed with water (50 mL) and dried in a vacuum oven at 55 °C overnight to provide 11.2 g of the title compound (96%).
References:
ABBVIE INC.;ABBOTT LABORATORIES TRADING (SHANGHAI) COMPANY, LTD.;WANG, Le;PRATT, John K.;MCDANIEL, Keith F.;DAI, Yujia;FIDANZE, Steven D.;HASVOLD, Lisa;HOLMS, James H.;KATI, Warren M.;LIU, Dachun;MANTEI, Robert A.;MCCLELLAN, William J;SHEPPARD, George S.;WADA, Carol K. WO2013/97601, 2013, A1 Location in patent:Page/Page column 89
![4-bromo-6-methyl-1H-pyrrolo[2,3-c]pyridin-7(6H)-one](/CAS/20180629/GIF/1361481-63-1.gif)
1361481-63-1
47 suppliers
inquiry
98-59-9
621 suppliers
$9.00/5g
1445993-87-2
58 suppliers
$445.00/1g
123-91-1
706 suppliers
$16.00/25g
74-88-4
349 suppliers
$15.00/10g
1445993-87-2
58 suppliers
$445.00/1g
884495-14-1
194 suppliers
$18.00/1g
1445993-87-2
58 suppliers
$445.00/1g
![4-bromo-7-methoxy-1-tosyl-1H-pyrrolo[2,3-c]pyridine](/CAS/20180629/GIF/1445993-85-0.gif)
1445993-85-0
30 suppliers
inquiry
1445993-87-2
58 suppliers
$445.00/1g