Methyl 2-(4-(4-chlorobutanoyl)phenyl)-2-methylpropanoate synthesis
- Product Name:Methyl 2-(4-(4-chlorobutanoyl)phenyl)-2-methylpropanoate
- CAS Number:154477-54-0
- Molecular formula:C15H19ClO3
- Molecular Weight:282.76
31469-15-5
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4559-96-0
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$30.00/10g
154477-54-0
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$115.00/500 mg
Yield:154477-54-0 85%
Reaction Conditions:
with zinc(II) fluoride;bis(acetylacetonato)palladium(II);tri-tert-butyl phosphine in DMF (N,N-dimethyl-formamide) at 80;Product distribution / selectivity;
Steps:
9
EXAMPLE 9; Two grams of 20, 170 mg of P(tBu)3, 560 mg of Pd(acac)2, 474 mg of ZnF2 and 2.0 g of 5 were combined in 50 mL of DMF under argon. The mixture was heated to 80° C. and monitored by HPLC. When reaction was complete, the mixture was cooled to room temperature and 250 mL of water was added. The mixture was extracted three times with ether, dried, filtered and reduced in vacuo. The resulting product was flash chromatographed in 4:1 hexane-ethyl acetate to provide 1.89 g (85%) of 8.
References:
AMR Technology, Inc. US2006/63933, 2006, A1 Location in patent:Page/Page column 12; 21
169280-21-1
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154477-54-0
192 suppliers
$115.00/500 mg
169280-21-1
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77-78-1
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$19.69/1ml
154477-54-0
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$115.00/500 mg
67-56-1
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169032-17-1
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154477-54-0
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$115.00/500 mg
162096-54-0
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$155.00/50mg
154477-54-0
192 suppliers
$115.00/500 mg