1,3-Benzenedicarboxamide, 5-(acetylamino)-N1,N3-bis[2,3-bis(acetyloxy)propyl]-2,4,6-triiodo- synthesis
- Product Name:1,3-Benzenedicarboxamide, 5-(acetylamino)-N1,N3-bis[2,3-bis(acetyloxy)propyl]-2,4,6-triiodo-
- CAS Number:174416-65-0
- Molecular formula:C24H28I3N3O11
- Molecular Weight:915.21
76801-93-9
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Yield:-
Reaction Conditions:
with toluene-4-sulfonic acid;acetic acid
Steps:
1 Example 1 : Acetylation of Compound B followed by deacetylation by state of art process and process of the invention to prepare Compound A.
Compound B was acetylated in a mixture of acetic anhydride and acetic acid. Paratoluene sulfonic acid (PTSA) was used as a catalyst. After acetylation, the solution was concentrated under reduced pressure, and then methanol and water was added prior to the deacetylation step. This solution (Compound B2 solution) was divided into two equal parts. One part was deacetylated according to current practice and the other part was deacetylated according to the process of the invention.
References:
WO2014/74315,2014,A1 Location in patent:Page/Page column 14
76801-93-9
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$23.00/25g
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64-19-7
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76820-35-4
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76820-34-3
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$160.00/500mg
174416-65-0
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13290-96-5
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