1H-1,2,4-Triazole-3-thiol synthesis
- Product Name:1H-1,2,4-Triazole-3-thiol
- CAS Number:3179-31-5
- Molecular formula:C2H3N3S
- Molecular Weight:101.13
64-18-6
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79-19-6
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$14.00/1g
3179-31-5
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$6.00/5g
Yield:3179-31-5 55%
Reaction Conditions:
Stage #1:formic acid;thiosemicarbazide in water at -10 - 105;
Stage #2: with sodium carbonate in water at 100; for 4 h;
Steps:
A Example A Synthesis of an intermediate 3-mercapto-1,2,4-triazole
Formic acid (24.2g, 0.52mol), water (25mL) and aminothiourea (20g, 0.22mol) were added to a 100mL reaction flask, heated to 105 ° C for half an hour; then slowly reduced to room temperature, then reduced Slow crystallization at -10 ° C;Finally, the solid was filtered to dry to give an aldehyde amine thiourea (white solid 22.3 g, yield: 85%).The aldehyde amine thiourea (12 g, 0.1 mol) was added to a 250 mL single-mouth bottle, and then water (130 mL) and sodium carbonate (21.2 g, 0.25 mol) were added, and the mixture was heated to 100 ° C for 4 hours;Then slowly reduce to room temperature, adjust the pH value to 4-5 with dilute hydrochloric acid, then slowly stir at -10 °C, slowly devitrify; filter out the solid, dry,5.6 g of a white solid were obtained in a yield of 55%.
References:
Dongguan Dongyang Guang Ke Research And Development Co., Ltd.;Li Yitao;Lin Jian;Yao Wenqiang;Xu Junxing;Wu Yang;Liu Xinshuo CN108689951, 2018, A Location in patent:Paragraph 0355; 0356; 0357; 0358
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3179-31-5
419 suppliers
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