2-(2'-BROMOPHENOXY)TETRAHYDRO-2H-PYRAN synthesis
- Product Name:2-(2'-BROMOPHENOXY)TETRAHYDRO-2H-PYRAN
- CAS Number:57999-46-9
- Molecular formula:C11H13BrO2
- Molecular Weight:257.12
95-56-7
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Yield:57999-46-9 100%
Reaction Conditions:
with 3,4-dihydro-2H-pyran;pyridinium p-toluenesulfonate in dichloromethane at 20; for 12 h;Inert atmosphere;
Steps:
4.1.15. 2-(2-Bromophenoxy)tetrahydropyran (18)
Under inert atmosphere, dihydropyran (3.96 mL, 1.5 eq.,43.35 mmol) was added to a solution of 2-bromophenol 17(3.35 mL, 1 eq., 28.90 mmol) in dichloromethane (35 mL). A catalyticamount of pyridinium p-toluenesulfonate (726 mg, 0.1 eq.,2.89 mmol) was then inserted in the flask, and the mixture wasstirred at room temperature for 12 h. The volatiles were thenremoved under reduced pressure, and the residue was purified bysilica gel column chromatography, eluting pure PE, to afford compound18 as a colorless oil. (7.43 g, quant.), [47]. CAS: 57999-46-9.
References:
Bessières, Maxime;Plebanek, El?bieta;Chatterjee, Payel;Shrivastava-Ranjan, Punya;Flint, Mike;Spiropoulou, Christina F.;Warszycki, Dawid;Bojarski, Andrzej J.;Roy, Vincent;Agrofoglio, Luigi A. [European Journal of Medicinal Chemistry,2021,vol. 214]
