2,2-Dimethyl-1,3-dioxane-4,6-dione synthesis
- Product Name:2,2-Dimethyl-1,3-dioxane-4,6-dione
- CAS Number:2033-24-1
- Molecular formula:C6H8O4
- Molecular Weight:144.13
Yield:2033-24-1 87.2%
Reaction Conditions:
Stage #1: malonic acidwith acetic anhydride;toluene-4-sulfonic acid for 0.5 h;Inert atmosphere;
Stage #2: acetone at 10 - 24; for 3 h;Inert atmosphere;Reagent/catalyst;Temperature;
Steps:
1-2 Preparation Example 2
Under nitrogen protection, in the reaction flask, add 227g of acetic anhydride, 213g of malonic acid and 13g of p-toluenesulfonic acid in sequence, stir for about 30min, control the temperature to 10°C, add 128g of acetone dropwise, and finish dropping in about 2 hours. Incubate the reaction at 24°C for about 1 hour, control in the middle, and the conversion rate of malonic acid is more than 99% as qualified, after passing, cool down to below -5°C, stir for crystallization for 1 hour, suction filter, and dry the filter cake to obtain Michael's acid. The yield was 87.2%.
References:
CN115141147,2022,A Location in patent:Paragraph 0041-0043
141-82-2
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