2',3'-Dideoxythymidine synthesis
- Product Name:2',3'-Dideoxythymidine
- CAS Number:3416-05-5
- Molecular formula:C10H14N2O4
- Molecular Weight:226.23
3056-17-5
469 suppliers
$5.00/25mg
3416-05-5
188 suppliers
$36.00/100mg
Yield:3416-05-5 85%
Reaction Conditions:
with hydrogen;5% palladium-on-charcoal in ethanol
Steps:
6 Example 6
Synthesis of Arylphosphate Derivatives of 3dT
By way of further comparison, the effect on anti-HIV activity of various substitutions in the aryl group of arylphosphate derivatives of 3'-deoxytbymidine (3dT) was studied. As shown in Scheme 2, 3dt 5 was prepared from d4T 1 which was prepared from thymidine using the literature procedure (Mansuri et al., 1989 J. Med. Chem. 32:461-466). Hydrogenation of 1 was carried out in ethanol in the presence of H2 and catalytic amount of 5% Pd/C to afford 3dT 5 in 85% yield.
References:
Parker Hughes Institute US6350736, 2002, B1 Location in patent:Page column 9
50-89-5
656 suppliers
$9.00/1g
3416-05-5
188 suppliers
$36.00/100mg
65-71-4
536 suppliers
$5.00/5g
3416-05-5
188 suppliers
$36.00/100mg
320-98-9
302 suppliers
$8.00/5g
18107-18-1
209 suppliers
$33.00/5g
3416-05-5
188 suppliers
$36.00/100mg
62435-72-7
32 suppliers
$173.00/5g
3416-05-5
188 suppliers
$36.00/100mg