2,4,5-Trifluorobenzyl bromide synthesis
- Product Name:2,4,5-Trifluorobenzyl bromide
- CAS Number:157911-56-3
- Molecular formula:C7H4BrF3
- Molecular Weight:225.01
243139-71-1
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$23.00/1g
157911-56-3
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$12.00/1g
Yield:157911-56-3 99%
Reaction Conditions:
with tetrabutylammonium bromide;hydrogen bromide at 100 - 110; for 15 h;Temperature;Reagent/catalyst;
Steps:
1-6 Example 1: Preparation of 2,4,5-trifluorobenzyl bromide
2L four-neck bottle, throw 2,4,5-trifluorobenzyl chloride 180.5g (1mol),675g (4mol) of 48% hydrobromic acid, 9g of tetrabutylammonium bromide, heat up to 100110 and keep reacting for 15h, cool to 2030 for layering,The lower oil layer was washed once with 180.5g deionized water,Dry under reduced pressure and dehydrate to moisture ≤ 0.5% to obtain 223 g of 2,4,5-trifluorobenzyl bromide,GC analysis: 2,4,5-trifluorobenzyl bromide 99.8%, yield 99%.
References:
CN114605223,2022,A Location in patent:Paragraph 0026-0037
144284-25-3
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157911-56-3
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50-00-0
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367-23-7
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157911-56-3
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165047-24-5
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157911-56-3
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446-35-5
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157911-56-3
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$12.00/1g