2,4-Dichlorobutyrophenone synthesis
- Product Name:2,4-Dichlorobutyrophenone
- CAS Number:66353-47-7
- Molecular formula:C10H10Cl2O
- Molecular Weight:217.09
2234-82-4
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Yield:-
Reaction Conditions:
in tetrahydrofuran;water;
Steps:
65.1 Synthesis of [4-(2,4-dichlorophenyl)-5-ethylpyrimid-2-yl]{2-[(5-nitro(2-pyridyl))amino]ethyl}amine
Step 1: A mixture of 2,4-dichlorobenzoyl chloride (4.5 g) and copper (I) iodide (200 mg) in dry THF (30 ml) was cooled to -20° C. under argon. Then a solution of n-propyl magnesium chloride (2 M in ether, 11.0 ml) was added dropwise. Ten minutes after addition was complete, the cooling bath was removed and the mixture stirred for 1 hour. Water was carefully added, followed by extraction with toluene. The toluene layer was washed with dilute HCl, water, saturated sodium bicarbonate solution, dried and concentrated in vacuo to give 1-(2,4-dichlorophenyl)butan-1-one (4.0 g).
References:
US2002/156087,2002,A1
53066-18-5
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