2,4-Dichloropyridine synthesis
- Product Name:2,4-Dichloropyridine
- CAS Number:26452-80-2
- Molecular formula:C5H3Cl2N
- Molecular Weight:147.99
14432-12-3
538 suppliers
$5.00/5g
26452-80-2
407 suppliers
$7.00/5g
Yield:26452-80-2 62%
Reaction Conditions:
with tert.-butylnitrite;copper dichloride in acetonitrile at 0 - 20; for 16 h;regioselective reaction;Sandmeyer Reaction;
Steps:
General procedure for the synthesis of substrates
General procedure: To a mixture of copper source (1.2 eq., CuBr2 for 4b, CuCl2 for 4c, CuI for 4d)in acetonitrile (0.4M) was slowly added tBuONO (1.5 eq.). The mixture was stirred for15 min and then cooled to 0°C. A solution of 2-chloro-4-aminopyridine 3 (1.0 eq.) inacetonitrile (0.5M) was slowly added. The mixture was stirred for 1h at 0°C and thenallowed to warm to r.t. for 16h. After concentration in vacuo, aq. 15% ammonia solution (1.3 mL/mmol) was added, and the aqueous layer was extracted withdichloromethane (10 mL/mmol; 3x). The combined organic layers were washed withbrine, dried (Na2SO4), filtered and carefully concentrated under reduced pressure(CAUTION: volatile products) to give the crude 4b-d, which was used in the next stepwithout purification.
References:
Honraedt, Aurélien;Gallagher, Timothy [Synlett,2016,vol. 27,# 1,art. no. ST-2015-D0455-L,p. 67 - 69] Location in patent:supporting information
1124-33-0
339 suppliers
$10.00/1g
26452-80-2
407 suppliers
$7.00/5g
16063-69-7
227 suppliers
$40.00/5g
109-09-1
0 suppliers
$10.60/1gm:
26452-80-2
407 suppliers
$7.00/5g
153034-86-7
387 suppliers
$10.00/1g
26452-80-2
407 suppliers
$7.00/5g
837365-03-4
4 suppliers
inquiry
26452-80-2
407 suppliers
$7.00/5g