2,4-Dichloropyrimidine synthesis
- Product Name:2,4-Dichloropyrimidine
- CAS Number:3934-20-1
- Molecular formula:C4H2Cl2N2
- Molecular Weight:148.98
66-22-8
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$5.00/10g
3934-20-1
727 suppliers
$9.00/1g
Yield:3934-20-1 95%
Reaction Conditions:
with dmap;thionyl chloride;bis(trichloromethyl) carbonate at 65 - 70;
Steps:
1 Example 1
Add 1000 mg of 2,4-dihydroxypyrimidine (8.9 mmol) to a 50 mL reaction flask.50mg DMAP and 4mL SOCl2,A turbid liquid is formed. A solution of 5.28 g (17.8 mmol) of BTC in SOCl 2 (4 mL) was slowly added dropwise.Heating in an oil bath, controlling the reaction temperature between 65 and 70 ° C,Cooling reflux reaction with frozen liquid. After the reaction was completed until the reaction of the starting material was completed, the reaction mixture was cooled, and the solvent was evaporated, and then added to 10 mL of ice water, neutralized with sodium carbonate solution to pH = 8 to 9, and extracted with dichloromethane, and the organic layer was separated.After washing with water, brine, and dried over anhydrous sodium sulfate, the solvent was evaporated (or purified) to give 2,4-dichloropyrimidine in a yield of 95%.
References:
CN110204495,2019,A Location in patent:Paragraph 0019; 0020
66-22-8
825 suppliers
$5.00/10g
3934-20-1
727 suppliers
$9.00/1g
7461-50-9
275 suppliers
$10.00/1g
3934-20-1
727 suppliers
$9.00/1g
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49844-90-8
253 suppliers
$5.00/1g
3934-20-1
727 suppliers
$9.00/1g