ChemicalBook CAS DataBase List 2,4-Difluorobenzoic acid

2,4-Difluorobenzoic acid synthesis

10synthesis methods

Product Name:2,4-Difluorobenzoic acid
CAS Number:1583-58-0
Molecular formula:C7H4F2O2
Molecular Weight:158.1

To a reaction vessel was added 2,4-dinitrotoluene, water, adjusted the pH to 7, and heated to 75 °C with stirring. Potassium permanganate, magnesium sulfate and phase transfer catalyst were added in batches. After the addition was completed, the reaction

3939-09-1 Synthesis

3939-09-1
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1583-58-0
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$6.00/5g

Yield:1583-58-0 92%

Reaction Conditions:

with 1-butyl-3-methylimidazolium hydrogen sulfate;water at 60 - 65; for 2.5 h;Green chemistry;

Steps:

General procedure for the synthesis of carboxylic acids from nitriles

General procedure: Aromatic or aliphatic nitriles (2 mmol) were dissolved in 5 ml of [bmim]HSO₄ and the reaction mixture was heated at 60-65 °C for 1-3 h. The progress of reaction was monitored by TLC. After completion of reaction, as checked by TLC, the reaction mixture was poured into water containing crushed ice. The product was precipitated out, filtered and dried. The yield of the final product was high (>90%) in all cases. All final products obtained were found sufficiently pure so it didn’t need further purification.The filtrate was concentrated under vacuum, washed with diethylether twice and concentrated under high vacuum. After proper drying under reduced pressure, approximately 95% ionic liquid was recovered from the reaction and compared with the original ionic liquid to check its authenticity. The efficiency of recovered ionic liquid in conversion of nitriles to acids was found unchanged in comparison to the original one and we reused it up to 5-6 cycles without any significant loss of its activity.

References:

Kumar, Satyanand;Dixit, Sandeep Kumar;Awasthi, Satish Kumar [Tetrahedron Letters,2014,vol. 55,# 28,p. 3802 - 3804] Location in patent:supporting information

364-83-0 Synthesis