2,6-Difluorobenzoic acid synthesis
- Product Name:2,6-Difluorobenzoic acid
- CAS Number:385-00-2
- Molecular formula:C7H4F2O2
- Molecular Weight:158.1
1897-52-5
550 suppliers
$7.00/10g
385-00-2
437 suppliers
$5.00/5g
Yield:385-00-2 85%
Reaction Conditions:
with water;sodium hydroxide at 150; under 1875.19 Torr; for 10 h;Autoclave;
Steps:
Add 139 g to the autoclave2,6-difluorobenzonitrile,120 g of sodium hydroxide and 180 g of water(The molar ratio of the three is 1: 3: 10), heated to 150 ° C, reacted for 10 hours, and the controlled pressure was 0.25 MPa.After completion of the reaction, the reaction solution was poured into a beaker,Adjust the pH value with 10% sulfuric acid aqueous solutionTo 1, precipitate slightly yellowish solid. By filtration, take solid phase with cold water washing, drying, and then 300mlEthanol and water volume ratio of 2: 1 mixed solution to recrystallize white crystal 6 - fluorosalic acid 168.2g.The yield of 6-fluorosalicylic acid was 85%.The purity of 6-fluorosalicylic acid was 98.5%.
References:
Yangzhou Tianchen Fine Chemical Co., Ltd;Chen, Guoyun;Wang, Chen;Pan, Mingsheng;Chen, Zhongcheng;Miao, Youchang;Liu, Runxing;Cai, Lei;Zhang, Xiaofeng;Luo, Rui CN106336352, 2017, A Location in patent:Paragraph 0013; 0014; 0015
124-38-9
724 suppliers
$175.00/23402
372-18-9
429 suppliers
$9.00/1g
385-00-2
437 suppliers
$5.00/5g
18063-03-1
531 suppliers
$8.00/10g
385-00-2
437 suppliers
$5.00/5g