2,6-Difluorobenzamide synthesis
- Product Name:2,6-Difluorobenzamide
- CAS Number:18063-03-1
- Molecular formula:C7H5F2NO
- Molecular Weight:157.12
1897-52-5
557 suppliers
$7.00/10g
18063-03-1
536 suppliers
$8.00/10g
Yield:18063-03-1 91.2%
Reaction Conditions:
with dihydrogen peroxide;sodium hydroxide at 50; for 5 h;Temperature;
Steps:
1.2; 2-10; 11-13; 14-20; 21-23; 24.2; 25.2; 26
(2) Add 30g (0.214mol) of 2,6-difluorobenzonitrile obtained in step (1) into a four-necked flask with stirring, thermometer and reflux condenser,25.62g (0.128mol) of 20% sodium hydroxide solution, heated to 50°C,Under stirring, add 72.61g (0.641mol) of 30wt% hydrogen peroxide dropwise, add dropwise for 3h, keep for 2h, and carry out the hydrolysis reaction; After the reaction is completed, the temperature drops to 25°C, add 10wt% hydrochloric acid to adjust the pH value to neutral (about 7.0), keep the temperature and stir for 1.5h,Cooling and suction filtration, adding water to wash the filter cake, and drying to obtain a solid product of 2,6-difluorobenzamide.
References:
CN112851539,2021,A Location in patent:Paragraph 0074; 0080-0081; 0082-0085; 0086-0090; 0091-0094
18063-02-0
265 suppliers
$12.00/5g
18063-03-1
536 suppliers
$8.00/10g
385-00-2
441 suppliers
$5.00/5g
18063-03-1
536 suppliers
$8.00/10g
437-81-0
376 suppliers
$9.00/5g
18063-03-1
536 suppliers
$8.00/10g
1897-52-5
557 suppliers
$7.00/10g
18063-03-1
536 suppliers
$8.00/10g
385-00-2
441 suppliers
$5.00/5g