2,6-Difluorobenzonitrile synthesis
- Product Name:2,6-Difluorobenzonitrile
- CAS Number:1897-52-5
- Molecular formula:C7H3F2N
- Molecular Weight:139.1
18063-03-1
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1897-52-5
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$7.00/10g
Yield:1897-52-5 87%
Reaction Conditions:
with Triethoxysilane;[cis-Fe(H)(SPh)(PMe3)4] in tetrahydrofuran at 60; for 24 h;Inert atmosphere;
Steps:
2.2. General procedure for the dehydration of amides to nitriles
General procedure: To a 25ml Schlenk tube containing a solution of 1 in 2ml of THF was added amide (1.0 mmol) and (EtO)3SiH (0.50 g, 3.0 mmol). The reaction mixture was stirred at 60 °C until there was no amide left (monitored by TLC and GC-MS). The product was purified according to literature procedures by Beller [27].
References:
Xue, Benjing;Sun, Hongjian;Wang, Yan;Zheng, Tingting;Li, Xiaoyan;Fuhr, Olaf;Fenske, Dieter [Catalysis Communications,2016,vol. 86,p. 148 - 150]
1194-65-6
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1897-52-5
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1194-65-6
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81175-49-7
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1897-52-5
556 suppliers
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1194-65-6
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81175-49-7
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350-46-9
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1897-52-5
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86225-73-2
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1897-52-5
556 suppliers
$7.00/10g