Pentafluorobenzonitrile synthesis
- Product Name:Pentafluorobenzonitrile
- CAS Number:773-82-0
- Molecular formula:C7F5N
- Molecular Weight:193.07
20925-85-3
199 suppliers
$6.00/1g
773-82-0
285 suppliers
$7.00/5g
Yield:773-82-0 270 kg
Reaction Conditions:
with potassium fluoride at 110 - 120; for 10 h;Inert atmosphere;Time;
Steps:
2.B; 4; 5.B; 6.B; 7.B; 8.B B. Fluorination reaction
Add 400kg of pentachlorobenzonitrile with stirring, heat the kettle to 110-120 by steaming through the jacket,After holding the reaction for 10 hours, evacuate and distill the product while reacting, and control the kettle temperature at 110-120 .The degree of vacuum is -0.07MPa to -0.08MPa, and 260kg of pentafluorobenzonitrile is obtained with a purity of 99.97%.Nitrogen is broken, then add 400kg pentachlorobenzonitrile, 500kg potassium fluoride,After incubating at 110-120 for 10 hours, the product is distilled while rectifying, and 270kg of pentachlorobenzonitrile can be obtained.The inorganic salt was centrifuged by cooling to 30-40 ° C, and the benzonitrile solvent was returned to the next batch.The combined yield of the two batches is 94.6%.
References:
Dalian Qikai Pharmaceutical Technology Co., Ltd.;Yuan Feng;Zhang Hongxue;Jiang Dianbao CN111004149, 2020, A Location in patent:Paragraph 0027-0029; 0042-0046; 0049-0052; 0055-0058; 0061
778-34-7
40 suppliers
$15.00/1g
773-82-0
285 suppliers
$7.00/5g
