Florfenicol synthesis
- Product Name:Florfenicol
- CAS Number:73231-34-2
- Molecular formula:C12H14Cl2FNO4S
- Molecular Weight:358.21
![Oxazole, 2-(dichloromethyl)-4-(fluoromethyl)-4,5-dihydro-5-[4-(methylsulfonyl)phenyl]-, (4S,5R)-](/CAS/20210305/GIF/143026-79-3.gif)
143026-79-3
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Yield:73231-34-2 99%
Reaction Conditions:
with hydrogenchloride in water;isopropyl alcohol at 70; pH=6; for 5 h;
Steps:
c.10
Take step b to obtain 34.02g (0.1mol) of compound III, and add it into a 250ml glass four-neck bottle,Add 70g of purified water and 75g of isopropanol, stir and mix, adjust the PH value to 6.0 with dilute hydrochloric acid, then heat to 70°C and keep hydrolyzing for 5.0h, and wait until the fluoride is completely hydrolyzed.Cool down to crystallize and keep at 05 to crystallize for 2h, filterThe white florfenicol was obtained, the weight was 35.46 g (0.099 mol), and the yield was 99.00%.
References:
CN112538034,2021,A Location in patent:Paragraph 0063-0065
126813-11-4
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![Benzenemethanol, α-[(1S)-2-fluoro-1-[(phenylmethyl)amino]ethyl]-4-(methylsulfonyl)-, (αR)-](/CAS/20210305/GIF/895571-10-5.gif)
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