ChemicalBook CAS DataBase List 2,4-DIFLUOROPHENYL ACETATE

2,4-DIFLUOROPHENYL ACETATE synthesis

5synthesis methods

Product Name:2,4-DIFLUOROPHENYL ACETATE
CAS Number:36914-77-9
Molecular formula:C8H6F2O2
Molecular Weight:172.13

367-27-1 Synthesis

367-27-1
344 suppliers
$6.00/5g

108-24-7
0 suppliers
$14.00/250ML

36914-77-9
32 suppliers
$45.00/250mg

Yield:36914-77-9 94 %Chromat.

Reaction Conditions:

with Magnetically separable γ-Fe₂O₃nanoparticles in neat (no solvent) at 28; for 1 h;Sealed tube;Sonication;

Steps:

2.4. General procedure for acylation reaction

General procedure: A 25mL sealed tube containing a magnetic stir bar was charged with phenol/alcohol/amine (1mmol) and acetic anhydride (1.5mmol), nano γ-Fe₂O₃ (5mol%, 8mg) as catalyst. The reaction mixture was kept for sonication in sonication bath at room temperature (28°C) for 1h. The ultrasonic bath (Labman Scientific Instruments, Model - LMUC 4) had a frequency of 33kHz and electric power rating of 100W. The reaction progress was monitored on thin-layer chromatography (TLC) and gas chromatography (PerkinElmer, GC Clarus 400) analysis. After completion of the reaction, the reaction mixture was diluted with ethyl acetate and catalyst was separated from reaction mixture by using a strong magnet. The separated catalyst was washed with distilled water and absolute ethanol several times then dried in oven and reused for further reaction. The reaction mixture was washed with saturated NaHCO₃ solution (1×15mL) and the product was extracted with ethyl acetate (3×10mL) and dried over Na₂SO₄ and evaporated under vacuum. All the obtained products are well known in the literature and were confirmed by gas chromatography-mass spectrometry (Shimadzu GCMS-QP 2010) analysis by comparison with literature data.

References:

Bhosale, Manohar A.;Ummineni, Divya;Sasaki, Takehiko;Nishio-Hamane, Daisuke;Bhanage, Bhalchandra M. [Journal of Molecular Catalysis A: Chemical,2015,vol. 404-405,p. 8 - 17]

367-27-1 Synthesis

367-27-1
344 suppliers
$6.00/5g

75-36-5 Synthesis