2,4-Difluorophenol synthesis
- Product Name:2,4-Difluorophenol
- CAS Number:367-27-1
- Molecular formula:C6H4F2O
- Molecular Weight:130.09
144025-03-6
367-27-1
General procedure for the synthesis of 2,4-difluorophenol from 2,4-difluorophenylboronic acid: arylboronic acid (1 mmol), 30% aqueous H2O2 solution (0.2 mL), ZnO nanocatalyst (5 mol%, sample ZnO-1), and 2 mL of water were stirred and mixed in a 50 mL round-bottomed flask at room temperature and under aerobic conditions. The reaction process was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the reaction mixture was diluted with 20 mL of water and extracted with ether (3 x 20 mL). The organic layers were combined, washed with brine and dried over Na2SO4. The solvent was removed by rotary evaporator under reduced pressure. The crude product was purified by silica gel (100-200 mesh) column chromatography (hexane/ethyl acetate, 9:1) to afford the target product 2,4-difluorophenol. The product structure was confirmed by 1H NMR and 13C NMR.
144025-03-6
389 suppliers
$6.00/1g
367-27-1
346 suppliers
$6.00/5g
Yield:367-27-1 92%
Reaction Conditions:
with dihydrogen peroxide in water at 20;chemoselective reaction;
Steps:
4 2.4. Ipso-hydroxylation of phenylboronic acid
General procedure: In a 50 mL round-bottomed flask, a mixture of arylboronic acid(1 mmol), H2O2 (30% aq, 0.2 mL), ZnO nanocatalyst (5 mol%; sampleZnO-1) and 2 mL of water were stirred at room temperature under aerobic condition. The progress of the reaction was monitored by thin layer chromatography (TLC). After completion of the reaction, the reaction mixture was diluted with 20 mL of water and extracted with (3×20) mL of diethyl ether. The combined organic layer was washed with brine and dried over Na2SO4. The solvent was removed in a rotary evaporator under reduced pressure. The crude product was purified by column chromatography (hexane/ ethylacetate, 9:1) on silica (100-200mesh) to get the desired product. The products were identified by 1HNMR and 13C NMR.
References:
Phukan, Shreemoyee;Mahanta, Abhijit;Rashid, Md. Harunar [Applied Catalysis A: General,2018,vol. 562,p. 58 - 66]
348-57-2
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367-27-1
346 suppliers
$6.00/5g
108-95-2
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$14.00/25g
371-41-5
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$8.00/25g
367-12-4
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$5.00/10g
367-27-1
346 suppliers
$6.00/5g
108-95-2
778 suppliers
$14.00/25g
371-41-5
542 suppliers
$8.00/25g
367-12-4
429 suppliers
$5.00/10g
367-27-1
346 suppliers
$6.00/5g
28177-48-2
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