4-Fluorophenol synthesis
- Product Name:4-Fluorophenol
- CAS Number:371-41-5
- Molecular formula:C6H5FO
- Molecular Weight:112.1
1765-93-1
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371-41-5
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Yield:371-41-5 98%
Reaction Conditions:
with dihydrogen peroxide at 30; for 5 h;Green chemistry;
Steps:
General procedure for the oxidation of boronic acids
General procedure: A mixture of boronic acid (1mmol), DMC (1.0mL) was taken in 25mL round bottom flask with magnetic stirring bar. Then the reaction was activated by addition of 30% H2O2 (2.0equiv.) and stirred at room temperature for 5h. The progress of reaction was monitored by TLC. After disappearance of starting material, added H2O (1.0mL) in to the reaction mixture. The reaction mixture was then further diluted with ethyl acetate (30mL) and subsequently washed with distilled water (5.0mL). The resulting organic extract was dried over anhydrous sodium sulphate. The solvent was removed under vacuum to get crude product which was purified (if necessary) by column chromatography using silica gel with pet ether and ethyl acetate as solvent system to obtain the pure product. The structure of the product was confirmed by GC-MS, M.P. and 1H NMR spectroscopic techniques.
References:
Wagh, Ravindra B.;Nagarkar, Jayashree M. [Tetrahedron Letters,2017,vol. 58,# 48,p. 4572 - 4575] Location in patent:supporting information
459-60-9
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371-41-5
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$8.00/25g
352-34-1
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371-41-5
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460-00-4
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371-41-5
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13990-72-2
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371-41-5
542 suppliers
$8.00/25g