2-(4-Iodo-phenoxy)-ethanol synthesis
- Product Name:2-(4-Iodo-phenoxy)-ethanol
- CAS Number:29639-77-8
- Molecular formula:C8H9IO2
- Molecular Weight:264.06
Yield:29639-77-8 95%
Reaction Conditions:
with potassium carbonate in N,N-dimethyl-formamide at 80; for 18 h;
Steps:
IV.2.a
2-(4-lodo-phenoxy)-ethanolA reaction mixture of 50 g (0,22 mol) 4-iodo-phenol, 18,298 ml (0,27 mol) 2-chloro-ethanol and 125,64 g (0,91 mol) potassium carbonate in 500 ml DMF is stirred at 800C for 16 hours. 3,6 ml 2-chloro-ethanol are added and the reaction mixture is stirred for another two hours at 80 0C. Then the reaction mixture is concentrated. 500 ml EtOAc are added to the residue and the resulting mixture is extracted with 400 ml of water and two times with 350 ml of 1 M sodium hydroxide solution. The organic phase is dried over magnesium sulphate and concentrated. Yield: 57,3 g (95% of theory),Rf value: 0.5 (silica gel, petrole ether/EtOAc = 1 :1 )
References:
WO2008/71646,2008,A1 Location in patent:Page/Page column 96
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