2,7-dichloro-4-methylquinoline synthesis
- Product Name:2,7-dichloro-4-methylquinoline
- CAS Number:59666-16-9
- Molecular formula:C10H7Cl2N
- Molecular Weight:212.08
2540-09-2
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59666-16-9
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Yield:59666-16-9 8.95 g (72%)
Reaction Conditions:
in trichlorophosphate;
Steps:
O.2 2,7-Dichloro-4-methylquinoline (14)
2,7-Dichloro-4-methylquinoline (14) A solution of quinolone 13 (10 g; 51.6 mmol) in 90 ml of POCl3 was refluxed for 2 hours. After cooling, the mixture was poured into 300 g ice-water and neutralized with NH4 OH. The resultant precipitate was filtered off and washed with cold H2 O. The crude product was recrystallized from 95% ethanol to obtain 8.95 g (72%) of 14. 1 H NMR (CDCl3): δ 2.71 (s, 3H); 7.28 (d, 1H); 7.55 (d, 1H); 7.92 (d, 1H); 8.08 (d, 1H).
References:
US5342946,1994,A
108-42-9
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59666-16-9
26 suppliers
$31.00/250mg