2',7'-Dichlorofluorescein synthesis
- Product Name:2',7'-Dichlorofluorescein
- CAS Number:76-54-0
- Molecular formula:C20H10Cl2O5
- Molecular Weight:401.2
Yield:76-54-0 88%
Reaction Conditions:
with Zn0.95*Ti0.05O in neat (no solvent) at 160; for 1.5 h;Green chemistry;
Steps:
2.3 General experimental procedure for fluorescein synthesis
General procedure: In a typical experimental procedure, phthalic anhydride (1 mmol), resorcinol (2 mmol) and Zn0.950Ti0.050O (10 mol%) catalyst were heated with constant stirring for 1.33h at 160°C and the progress of the reaction was monitored by TLC. After the completion of reaction, the reaction mixture was dissolved in 1N NaOH (10 mL) and the catalyst was separated using centrifugation. The filtrate was acidified using 1N HCl until the solution was neutralized. During neutralization, the precipitation of the dye was observed which was further purified by recrystallization with methanol.
References:
Jadhav, Nirajkumar H.;Shinde, Dnyaneshwar R.;Sakate, Sachin S.;Rasal, Nishant K.;Pawar, Ramdas A. [Catalysis Communications,2019,vol. 120,p. 17 - 22]
518-45-6
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