2-Acetylbenzimidazole synthesis
- Product Name:2-Acetylbenzimidazole
- CAS Number:18773-95-0
- Molecular formula:C9H8N2O
- Molecular Weight:160.17
51-17-2
591 suppliers
$14.00/25g
64-19-7
1724 suppliers
$10.00/25ML
18773-95-0
44 suppliers
$324.00/5g
Yield:18773-95-0 100 %
Reaction Conditions:
with acetic anhydride at 20;
Steps:
4.4.3.12. 1-(1H-Benzo[d]imidazole-1-yl)ethan-1-one (3l)
Benzimidazole(0.20 g, 1.7 mmol), Ac2O (3.5 mL, 37.0 mmol) and AcOH (5.0 mL,87.3 mmol) were stirred at RT for 0.5 h. The reaction mixture wasconcentrated under reduced pressure, and then azeotroped with PhMe(x3) to give 1-(1H-benzo[d]imidazole-1-yl)ethan-1-one (270 mg,quant.) as an off-white solid.1H NMR (600 MHz, DMSO-d6) 8.89 (s, 1H), 8.17 (d, J = 7.5 Hz, 1H), 7.76 (d, J = 7.9 Hz, 1H), 7.44-7.35 (m, 2H), 2.75 (s, 3H); 13C NMR(151 MHz, DMSO-d6) 169.1, 144.2, 143.7, 131.2, 125.3, 124.6, 120.0,115.2, 23.7; LCMS m/z 161.0 [M+H]+.
References:
Atkinson, Benjamin N.;Willis, Nicky J.;Zhao, Yuguang;Patel, Chandni;Frew, Sarah;Costelloe, Kathryn;Magno, Lorenza;Svensson, Fredrik;Jones, E. Yvonne;Fish, Paul V. [European Journal of Medicinal Chemistry,2023,vol. 251,art. no. 115132]
51-17-2
591 suppliers
$14.00/25g
75-36-5
578 suppliers
$17.92/100G
18773-95-0
44 suppliers
$324.00/5g
51-17-2
591 suppliers
$14.00/25g
108-24-7
0 suppliers
$14.00/250ML
18773-95-0
44 suppliers
$324.00/5g
583-39-1
762 suppliers
$13.00/25g
18773-95-0
44 suppliers
$324.00/5g
6299-92-9
35 suppliers
$46.10/1g
546-67-8
242 suppliers
$10.00/10g
18773-95-0
44 suppliers
$324.00/5g
52096-23-8
0 suppliers
inquiry