ChemicalBook CAS DataBase List Benzimidazole

Benzimidazole synthesis

12synthesis methods

Product Name:Benzimidazole
CAS Number:51-17-2
Molecular formula:C7H6N2
Molecular Weight:118.14

Benzimidazole is synthesized by cyclizing o-phenylenediamine with formic acid. A mixture of o-phenylenediamine and formic acid is heated in a water bath for 2 hours, then cooled. The pH is adjusted to 10 using 10% sodium hydroxide solution, followed by filtration of the precipitated solid. The solid is washed with cold water to obtain the crude product (yield: 90%). The crude product is then refluxed in water, decolorized with activated carbon, and hot-filtered. Upon cooling the filtrate to room temperature, the purified product is collected by filtration, washed with cold water, and dried at 100°C to obtain the final product.

50-00-0 Synthesis

50-00-0
911 suppliers
$10.00/25g

95-54-5 Synthesis

95-54-5
543 suppliers
$9.00/1g

51-17-2
594 suppliers
$14.00/25g

Yield:51-17-2 93%

Reaction Conditions:

with zinc oxide nanoparticle in ethanol at 25; for 0.166667 h;Sonication;Green chemistry;

Steps:

2.4. Synthesis of 2-benzimidazoles derivatives using ZnO NPs as catalyst
General procedure: In a typical procedure, aldehyde (10 mmol) and o-phenylenediamine(10 mmol) was dissolved in 10 ml ethanol. To this 0.5 mol% of ZnO (4.1 mg) nanocatalyst was added to the solution. The mixture was sonicated at a room temperature (25 °C) with ultrasound irradiation for 10 min. After completion of the reaction as indicated by the TLC, the reaction mixture was poured in ice cold water. The solid was filtered and the product was washed with water twice, dried and then purified by recrystallization from ethanol

References:

Paul, Bappi;Vadivel, Sethumathavan;Dhar, Siddhartha Sankar;Debbarma, Shyama;Kumaravel [Journal of Physics and Chemistry of Solids,2017,vol. 104,p. 152 - 159]

934-32-7 Synthesis