2-Amino-4-methylthiazole synthesis
- Product Name:2-Amino-4-methylthiazole
- CAS Number:1603-91-4
- Molecular formula:C4H6N2S
- Molecular Weight:114.17
Yield:1603-91-4 90%
Reaction Conditions:
with N-iodo-succinimide in ethanol at 20; for 1 h;
Steps:
2.4. General procedure for the synthesis of 2-aminothiazoles
General procedure: A mixture of methyl carbonyl (2 mmol), thiourea (3 mmol), NIS(2 mmol), and NH2-MMT (0.10 g) in EtOH (5 mL) at room temperature was stirred until completion of reaction. The progress of the reaction was monitored by TLC (petroleum ether-ethyl acetate 4:1). After completion of the reaction, the NH2-MMT was separated by filtration. After evaporation of EtOH under vacuum, the crude product was dissolved in boiling water and adjusted to pH 8 withthe amount of ammonia to give the solid products. The solid obtained was recrystallized from a mixture of ethanol-water.
References:
Zarnegar, Zohre;Alizadeh, Roghayeh;Ahmadzadeh, Majid;Safari, Javad [Journal of Molecular Structure,2017,vol. 1144,p. 58 - 65]
