2-BROMO-4-METHYL-6-NITROPHENOL synthesis
- Product Name:2-BROMO-4-METHYL-6-NITROPHENOL
- CAS Number:20039-91-2
- Molecular formula:C7H6BrNO3
- Molecular Weight:232.03
6627-55-0
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Yield: 74%
Reaction Conditions:
with sulfuric acid;nitric acid in water at 0 - 20;
Steps:
48.1 Step 1: Example 48b
To a solution of H2SO4 (200 mL) in H2O (620 mL) was added HNO3 (56 g, 889 mmol) at 0oC. Then Example 48a (88 g, 471 mmol) was added and the resulting mixture was stirred at r.t. for overnight. After completion, the mixture was extracted by EtOAc, and dried over anhydrous Na2SO4. The solution was concentrated under reduced pressure, which was purified by silica gel column chromatography to give Example 48b (81 g, yield: 74%) as a yellow solid.
References:
FRONTHERA U.S. PHARMACEUTICALS LLC;JIN, Bohan;DONG, Qing;HUNG, Gene WO2020/185755, 2020, A1 Location in patent:Paragraph 00578
2432-14-6
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119-33-5
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106-44-5
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