2-BroMo-5-chlorophenylacetonitrile synthesis
- Product Name:2-BroMo-5-chlorophenylacetonitrile
- CAS Number:127792-49-8
- Molecular formula:C8H5BrClN
- Molecular Weight:230.49
333-20-0
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Yield:-
Reaction Conditions:
in ethanol;water for 4 h;Reflux;
Steps:
Synthesis of 2-(2-(dibenzylamino)ethyl)benzaldehyde (s6):
General procedure: To a solution of commercially available s1 (1.84 g, 7.36 mmol) in EtOH (10.0 mL) and H2O (5.0mL) was added KCN (1.29 g, 19.9 mmol) at room temperature. After the mixture was heated toreflux for 4 h, the reaction was quenched by addition of H2O. The crude mixture was extractedwith CH2Cl2 (x3) and the combined organic extracts were washed with brine, dried (Na2SO4), andconcentrated in vacuo to give crude s2 (1.55 g) as pale red oil. This crude material was used fornext reaction without further purification.
References:
Machida, Mizuki;Mori, Keiji [Chemistry Letters,2018,vol. 47,# 7,p. 868 - 871] Location in patent:supporting information
151-50-8
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112399-50-5
240 suppliers
$7.00/5g
127792-49-8
48 suppliers
inquiry