2-BROMO-5-NITROBENZOIC ACID synthesis
- Product Name:2-BROMO-5-NITROBENZOIC ACID
- CAS Number:943-14-6
- Molecular formula:C7H4BrNO4
- Molecular Weight:246.01
88-65-3
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$5.00/5g
943-14-6
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$17.50/1g
Yield: 96%
Reaction Conditions:
with sulfuric acid;nitric acid at 5; for 1 h;
Steps:
2-bromo-5-nitrobenzoic acid (4i1).
Commercially available 2-bromobenzoic acid (9.90 g, 49.3 mmol) was added to an ice cold mixture of 25 mL H2SO4 and 12 mL of HNO3. The reaction was stirred for 1 hr while keeping the temperature maintained below 5 °C. The reaction was poured into a 200 mL beaker containing ice water. The white solid product was obtained by vacuum filtering for 1 hr (11.6 g, 96%). mp = 180-181 °C. 1H NMR (400 MHz, DMSO-d6): δ 8.49 (d, J = 2.8 Hz, 1 H), 8.22 (dd, J = 8.8, 2.8 Hz, 1 H), 8.03 (d, J = 8.8 Hz, 1 H). The experimental m.p. matches the known m.p. (181°C).
References:
Carlson, Erik J.;Riel, Asia Marie S.;Dahl, Bart J. [Tetrahedron Letters,2012,vol. 53,# 46,p. 6245 - 6249,5] Location in patent:supporting information
7149-70-4
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$9.00/1g
943-14-6
178 suppliers
$17.50/1g
2142-69-0
334 suppliers
$6.00/1g
943-14-6
178 suppliers
$17.50/1g
99-08-1
229 suppliers
$5.00/5 g
943-14-6
178 suppliers
$17.50/1g
