一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

Welcome to chemicalbook!
Chinese English Japanese Germany Korea
010-86108875
Try our best to find the right business for you.
Do not miss inquiry messages Please log in to view all inquiry messages.

Welcome back!

ChemicalBook CAS DataBase List 2-bromo-6-phenoxypyridine
83247-00-1

2-bromo-6-phenoxypyridine synthesis

2synthesis methods
-

Yield: 93%

Reaction Conditions:

with potassium tert-butylate in dimethyl sulfoxide at 160; for 7 h;

Steps:

16
Preparation Example 16. C-(6-Phenoxy-pyridin-2-yl)-methylamine To a solution of 2,6-dibromopyridine (20g, 84.4mmol) and phenol (7.94g, 84.4mmol) in dimethylsulfoxide (200mL) was added potassium tert-butoxide (9.47g, 84.4mmol), and the solution was stirred at 160°C for 7 hours. The reaction solution was allowed to room temperature, ethyl acetate and water were added for partitioning, the organic layer was washed with water and dried over anhydrous magnesium sulfate. The solvent was evaporated, the residue was purified by silica gel column chromatography (hexane : ethyl acetate = 10 : 1), and 2-bromo-6-phenoxy-pyridine (19.6g, 93%) was obtained as a yellow solid. Next, to a solution of the resulting 2-bromo-6-phenoxy-pyridine (1.0g, 4.0mmol) in N,N-dimethylformamide (30mL) were added zinc cyanide (940mg, 8.0mmol) and tetrakis(triphenylphosphine)palladium(0) (924mg, 0.8mmol) under nitrogen atmosphere, and the mixture was stirred at 100°C for 1 hour. The reaction mixture was allowed to room temperature, ethyl acetate and water were added for partitioning, the organic layer was washed with water and dried over anhydrous magnesium sulfate. The solvent was evaporated, the residue was purified by silica gel column chromatography (hexane : ethyl acetate = 10 : 1), and 6-phenoxy-pyridine-2-carbonitrile (524mg, 67%) was obtained as a white solid. 10% Palladium-carbon (50mg) was added to a solution of the resulting 6-phenoxy-pyridine-2-carbonitrile (100mg, 0.51mmol) in methanol (5.0mL), the mixture was stirred at room temperature for 24 hours under hydrogen atmosphere (1 atm). The catalyst was removed by filtration, and the filtrate was concentrated to obtain the title compound (65mg, 64%) as a colorless oil.

References:

Eisai R&D Management Co., Ltd. EP1782811, 2007, A1 Location in patent:Page/Page column 70-71

香港| 重庆市| 遵化市| 临沭县| 平定县| 张家港市| 石台县| 吴旗县| 碌曲县| 安乡县| 安乡县| 祥云县| 那曲县| 平定县| 嘉定区| 景泰县| 鹤山市| 梁河县| 河北区| 紫金县| 凤庆县| 万全县| 洛阳市| 保康县| 同德县| 繁峙县| 吉林市| 津市市| 水富县| 正安县| 和田市| 肃北| 潞城市| 盐边县| 宾阳县| 永城市| 汝南县| 康保县| 涿鹿县| 舒兰市| 南城县|