2-Bromoadamantane synthesis
- Product Name:2-Bromoadamantane
- CAS Number:7314-85-4
- Molecular formula:C10H15Br
- Molecular Weight:215.13
281-23-2
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$5.00/25g
768-90-1
422 suppliers
$10.00/5g
7314-85-4
185 suppliers
$18.00/1g
876-53-9
250 suppliers
$25.00/5g
Yield:768-90-1 35 %Spectr. ，7314-85-4 14 %Spectr. ，876-53-9 11 %Spectr.
Reaction Conditions:
with tert-butyl hypobromite;carbon tetrabromide in dichloromethane at 40; for 90 h;Darkness;Reagent/catalyst;
Steps:
Table S2, entry 3
tert-Butyl hypobromite 50 (0.33 mL, freshly prepared and used immediately, 0.05 mmol, 0.1 eq.), adamantane 18 (68 mg, 0.5 mmol), carbon tetrabromide (166 mg, 0.5 mmol, 1 eq.) and dichloromethane (3.13 mL) were added to an oven-dried pressure tube and the reaction mixture was stirred at 40 °C for 90 h in the dark. The reaction mixture was cooled to RT and quenched with aqueous hydrochloric acid (1 M, 5 mL) and extracted with dichloromethane (4 x 10 mL). The organic phases were combined, dried over Na2SO4, filtered and concentrated in vacuo. The yield of adamantane 18 (29%), 1-bromoadamantane 31 (35%), 2-bromoadamantane 51 (14%) and 1,3-bromoadamantane 52 (11%) were determined by adding 1,3,5-trimethoxybenzene to the crude mixture as an internal standard for 1H-NMR.
References:
Emery, Katie J.;Young, Allan;Arokianathar, J. Norman;Tuttle, Tell;Murphy, John A. [Molecules,2018,vol. 23,# 5,art. no. 1055] Location in patent:supporting information
935-56-8
207 suppliers
$34.50/5g
768-90-1
422 suppliers
$10.00/5g
7314-85-4
185 suppliers
$18.00/1g
281-23-2
511 suppliers
$5.00/25g
876-53-9
250 suppliers
$25.00/5g
![Tricyclo[3.3.1.13,7]decan-2-ol, 2-methanesulfonate](/CAS/20210305/GIF/31616-68-9.gif)
31616-68-9
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7314-85-4
185 suppliers
$18.00/1g
700-57-2
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7314-85-4
185 suppliers
$18.00/1g