ChemicalBook CAS DataBase List 2-Chloro-4,5-diaminopyrimidine

2-Chloro-4,5-diaminopyrimidine synthesis

1synthesis methods

Product Name:2-Chloro-4,5-diaminopyrimidine
CAS Number:14631-08-4
Molecular formula:C4H5ClN4
Molecular Weight:144.56

A mixture of 2-chloro-5-nitropyrimidin-4-amine (1.0 g, 5.7 mmol) and SnCl2·2H2O (5.2 g, 22.9 mmol) in EtOH (55 mL) under N2 was heated to 80 °C and stirred for two hours. The mixture was then concentrated under reduced pressure. EtOAc and Celite were added to the residue, and the mixture was basified with saturated Na2CO3 (aq.) to pH 9- 10. The mixture was filtered through a pad of Celite and washed with EtOAc. The organic layer was separated, washed with brine, dried (Na2SO4), and concentrated in a vacuum. The residue was purified on ISCO (20 g silica gel column, EtOAc/hexanes 0~100 per cent) to give 2-Chloro-4,5-diaminopyrimidine (0.41 g 49 per cent).

1920-66-7
137 suppliers
$20.00/1g

14631-08-4
157 suppliers
$19.00/100mg

Yield: 54.5%

Reaction Conditions:

with water;iron;ammonium chloride in ethanol at 100; for 4 h;

Steps:

21 Synthesis of Compound 21-3
To a solution of compound 21-2 (20 g, 114.6 mmol) in EtOH/H₂O (4/1, 400 mL) was added iron powder (64 g, 1146 mmol) and NH₄Cl (aq., 62 g, 1146 mmol), the reaction solution was stirred at 100° C. for 4 h, followed by filtration. The filter cake was washed with MeOH (10 mL×3) and the filtrate was concentrated to give compound 21-3 (9 g, Yield 54.5%) as yellow solid.

References:

Hubei Bio-Pharmaceutical Industrial Technological Institute Inc.;Humanwell Healthcare (Group) Co., Ltd.;Wang, Xuehai;Wu, Chengde;Xu, Yong;Shen, Chunli;Li, Li'e;Hu, Guoping;Yue, Yang;Li, Jian;Guo, Diliang;Shi, Nengyang;Huang, Lu;Chen, Shuhui;Tu, Ronghua;Yang, Zhongwen;Zhang, Xuwen;Xiao, Qiang;Tian, Hua;Yu, Yanping;Chen, Hailiang;Sun, Wenjie;He, Zhenyu;Shen, Jie;Yang, Jing;Tang, Jing;Zhou, Wen;Yu, Jing;Zhang, Yi;Liu, Quan US2017/313683, 2017, A1 Location in patent:Paragraph 0544

2-Chloro-4,5-diaminopyrimidine Related Search:

2-Chloro-6-methylpyrimidine-4,5-diamine 4-AMINO-6-CHLOROPYRIMIDIN-5-YLAMINE 2,6-Diamino-4-chloropyrimidine 1-oxide

HomePage | About Us | Member Companies | Advertising | Contact us | Previous WebSite | MSDS | CAS Index | CAS DataBase | Product Catalog | Links | Privacy | Terms | Product Manufacturers | New Products
All products displayed on this website are only for non-medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.
According to relevant laws and regulations and the regulations of this website, units or individuals who purchase hazardous materials should obtain valid qualifications and qualification conditions.

一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

2-Chloro-4,5-diaminopyrimidine synthesis

2-Chloro-4,5-diaminopyrimidine Related Search: