ChemicalBook CAS DataBase List 2-Chloro-4-hydroxypyridine

2-Chloro-4-hydroxypyridine synthesis

7synthesis methods

Product Name:2-Chloro-4-hydroxypyridine
CAS Number:17368-12-6
Molecular formula:C5H4ClNO
Molecular Weight:129.54

2-Chloro-4-hydroxypyridine can be produced by the reaction of chloroform and pyridine, which results in the formation of 2-chloro-4-hydroxypyridine.

14432-12-3 Synthesis

14432-12-3
545 suppliers
$5.00/5g

17368-12-6
287 suppliers
$4.00/1g

Yield:17368-12-6 92%

Reaction Conditions:

Stage #1:4-Amino-2-chloropyridine with sulfuric acid;sodium nitrite in water at 0 - 20; for 24 h;
Stage #2: with sodium hydroxide in water

Steps:

1
In a recovery flask, 4-amino-2-chloropyridine (3.0 g, 23.3 mmol) was dissolved in 40% sulfuric acid (50 g) . While the solution was stirred at 0⁰C, sodium nitrite (1.93 g, 28.0 mmol) was added. The mixture was stirred at room temperature for 24 hours. After the reaction completed, the reaction liquid was neutralized by adding an aqueous sodium hydroxide solution and an aqueous sodium hydrogencarbonate solution. The organic phase was extracted with ethyl acetate. The organic phase was then dried over magnesium sulfate, filtered, distilled to remove the solvent, and dried under reduced pressure to give 2-chloro-4-hydroxypyridine (light brown solid). The solid weighed 2.78 g, and the yield was 92%. [0088]¹H-NMR (270 MHz, DMSO-d6) ppm: 11.20 (s, IH, -OH), 8.09 (d, IH, J = 5.4 Hz, ArH), 6.81 (s, IH, ArH), 6.77 (d, IH, J = 2.2 Hz, ArH)

References:

SHOWA DENKO K.K. WO2009/11447, 2009, A2 Location in patent:Page/Page column 37-38

FullText

17228-69-2
215 suppliers
$10.00/1g

17368-12-6
287 suppliers
$4.00/1g

References

23056-36-2 Synthesis

23056-36-2
372 suppliers
$6.00/1g

17368-12-6
287 suppliers
$4.00/1g

References

458532-96-2 Synthesis

458532-96-2
276 suppliers
$6.00/250mg

17368-12-6
287 suppliers
$4.00/1g

References

73583-37-6 Synthesis

73583-37-6
335 suppliers
$9.00/1g

17368-12-6
287 suppliers
$4.00/1g

References

2-Chloro-4-hydroxypyridine Related Search:

2-Chloro-4-bromopyridine Clopidol 2-Chloro-5-(chloromethyl)pyridine 4-Hydroxypyridine 2-Chloro-4-fluoropyridine 2,3,5,6-TETRAFLUOROTHIOPHENOL PENTAFLUOROBENZENESULFONYL CHLORIDE 2-Chloro-3-hydroxypyridine 6-Chloropyridn-2-ol 2-Chloro-5-hydroxypyridine

HomePage | About Us | Member Companies | Advertising | Contact us | Previous WebSite | MSDS | CAS Index | CAS DataBase | Product Catalog | Links | Privacy | Terms | Product Manufacturers | New Products
All products displayed on this website are only for non-medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.
According to relevant laws and regulations and the regulations of this website, units or individuals who purchase hazardous materials should obtain valid qualifications and qualification conditions.

一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

2-Chloro-4-hydroxypyridine synthesis

2-Chloro-4-hydroxypyridine Related Search: