2-Chloro-5-hydroxypyrimidine synthesis
- Product Name:2-Chloro-5-hydroxypyrimidine
- CAS Number:4983-28-2
- Molecular formula:C4H3ClN2O
- Molecular Weight:130.53
22536-65-8
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4983-28-2
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$6.00/250mg
Yield:4983-28-2 91%
Reaction Conditions:
with hydrogen bromide;DL-methionine in acetic acid; for 5 h;Reflux;
Steps:
1-4 Example 3
Prepare 1L four-necked flask with a stirring device and thermometer.Add 100 g of 2-chloro-5-methoxypyrimidine,300 mL of acetic acid was added to the reaction flask,Stir well, then add 153g of 48% hydrobromic acid and 1g of methionine.Warming up to reflux reaction for 5 h,Sampling HPLC controlled until the end of the reaction, product content 96%, dihydroxy by-product 0.5%;After dropping to room temperature, 300 mL of water was added to the reaction solution, and the mixture was extracted three times with 300 mL of dichloromethane.The organic phases were combined and washed with saturated sodium bicarbonate solution.Then, it is dried over anhydrous sodium sulfate, and after filtration, the organic phase is concentrated under reduced pressure to give a crude product;The crude product was recrystallized from the crude product to give a pale yellow solid, 82 g.The yield was 91% and the purity was 98%.
References:
CN110041269,2019,A Location in patent:Paragraph 0006; 0012-0015
56621-90-0
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4983-28-2
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$6.00/250mg
1003845-06-4
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4983-28-2
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56622-03-8
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4983-28-2
272 suppliers
$6.00/250mg