2-Chloropyrazine synthesis
- Product Name:2-Chloropyrazine
- CAS Number:14508-49-7
- Molecular formula:C4H3ClN2
- Molecular Weight:114.53
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14508-49-7
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Yield:14508-49-7 95.4%
Reaction Conditions:
with thionyl chloride;N-ethyl-N,N-diisopropylamine in chloroform at 65; for 2 h;Reagent/catalyst;
Steps:
1.c; 4-5
(c) Add 0.05 mol of dichlorosulfoxide, 0.5 mmol N,N-diisopropylethylamine and chloroform to a three-necked flask, and raise the temperature to 65°C,After adding 0.05mol of 2-hydroxypyrazine sodium salt and holding the reaction for 2h,The reaction solution was cooled to room temperature, and then slowly poured into an appropriate amount of ice water for hydrolysis,Then adjust the pH to 7-8 with 1N sodium hydroxide solution and distill,Fractions from 98 to 101°C were collected. Extract the resulting fraction,The lower product 2-chloropyrazine 5.46g was separated with a yield of 95.4%.
References:
CN111004187,2020,A Location in patent:Paragraph 0034; 0038-0039; 0047-0052
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14508-49-7
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