一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

Welcome to chemicalbook!
Chinese English Japanese Germany Korea
010-86108875
Try our best to find the right business for you.
Do not miss inquiry messages Please log in to view all inquiry messages.

Welcome back!

ChemicalBook CAS DataBase List Hydrochlorothiazide
58-93-5

Hydrochlorothiazide synthesis

5synthesis methods
Hydrochlorothiazide, 1,1-dioxide 6-chloro-3,4-dihydro-2H-1,2,4- benzothiadiazin-7-sulfonamide (21.3.4), is synthesized either by cyclization of 4,6-sulfonamido- 3-chloroaniline (21.3.2) using paraformaldehyde, during which simultaneous reduction of the double bond occurs at position C3–C4, or the drug is synthesized by reduction of the same double bond in chlorothiazide (21.3.3) by formaldehyde. This small change in structure increases activity of the drug in comparison with chlorothiazide, and increases its absorbability when used orally.

-

Yield:58-93-5 93.9%

Reaction Conditions:

with potassium borohydride;acetic acid in methanol at -10 - 5; for 4 h;Reagent/catalyst;Solvent;

Steps:

2 6-Chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide-1,1-dioxidePreparation of matter

potassium borohydride (3.65 g, 67.6 mmol, 2 eq) was added to methanol (50 mL).The temperature was lowered to 0 to 5 ° C, and acetic acid (8.11 g, 135.2 mmol, 4 eq) was added dropwise at this temperature.After stirring for 1~2h,Cool down to -10 ° C,The compound chlorothiazide (10 g, 33.8 mmol, 1 eq) was added at this temperature.Maintain -10 ~ 5 ° C reaction for 4h,Filter by suction and rinse the filter cake with a small amount of methanol (10 mL).Get about 9.4g of white solid(Yield 93.9%).

References:

CN108658896,2018,A Location in patent:Paragraph 0063; 0067-0069; 0075; 0081; 0088; 0095; 0101

Hydrochlorothiazide Related Search:

福海县| 巴塘县| 郴州市| 永胜县| 竹山县| 满洲里市| 卢湾区| 凯里市| 皮山县| 富顺县| 广灵县| 荥阳市| 鄂托克前旗| 麦盖提县| 新干县| 平邑县| 海南省| 和龙市| 象州县| 双城市| 佳木斯市| 张家港市| 临泉县| 察雅县| 泽库县| 海口市| 缙云县| 宁乡县| 屏东县| 东乡县| 罗山县| 平陆县| 四子王旗| 兴宁市| 肇庆市| 西盟| 南陵县| 新龙县| 杭州市| 福鼎市| 万山特区|