NSC525339 synthesis
- Product Name:NSC525339
- CAS Number:89813-56-9
- Molecular formula:C7H6ClN3O5S2
- Molecular Weight:311.72
121-30-2
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Yield:-
Reaction Conditions:
with urea in water;
Steps:
15.b (b)
(b) 4-Amino-6-chloro-N3 -methyl-1,3-benzenedisulfonamide A mixture of 4-amino-6-chloro-1,3-benzenedisulfonamide (30 g., 105 mmole) and urea (12.6 g., 210 mmole) are ground together and then heated in a 200°-205° oil bath. Within 30 minutes the sample is a molten foam, which in another 30 minutes resolidifies. After a further 30 minutes heating, the flask is cooled and the contents slurried in water and acidified. The cream-colored powder is filtered, washed with water, and dried azeotropically with benzene to yield 31 g. of 6-chloro-3,4-dihydro-3-oxo-2H-1,2,4-benzothiadiazine-7-sulfonamide, 1,1-dioxide.
References:
US4681886,1987,A
