2-ethynylpyrazine synthesis
- Product Name:2-ethynylpyrazine
- CAS Number:153800-11-4
- Molecular formula:C6H4N2
- Molecular Weight:104.11
![2-[2-(trimethylsilyl)ethynyl]pyrazine](/CAS/20200401/GIF/291763-66-1.gif)
291763-66-1
153800-11-4
To a solution of compound (CAS:291763-66-1) (3.0 g, 17.02 mmol) in THF (10 mL) was slowly added 1 M TBAF (tetrabutylammonium fluoride) solution over 9 min. The progress of the reaction was monitored by TLC (Thin Layer Chromatography) to confirm the complete conversion of the feedstock to the target product 2-alkynylpyrazines. After completion of the reaction, the mixture was concentrated under reduced pressure to remove the solvent. The crude product was purified by silica gel column chromatography to give 2-alkynylpyrazines (1.0 g, yield: 56.5%). LC-MS (Liquid Chromatography-Mass Spectrometry) analysis showed: m/z 105 ([M+H]+).
291763-66-1
5 suppliers
inquiry
153800-11-4
68 suppliers
$45.00/10mg
Yield: 56.5%
Reaction Conditions:
with tetrabutyl ammonium fluoride in tetrahydrofuran for 0.05 h;
Steps:
3 Procedure for preparation of2ethyny1pyraziaie:
To a solution of 9(3.Og, 17.O2rnrnoi) in iOmL THE was added IM of TBAF over 3 minutes. TLC analysis showed complete conversion of starting material to a major product. The reactionmixture was then concentrated in vacuo. The crude product was purified by silica gel column chromatography to give product 10(1.0g. yield: 56.5%).LCMS: m/ 105 (M+H).
References:
HUA MEDICINE (SHANGHAI) LTD.;CHEN, Li;JIN, Xiaowei WO2017/117708, 2017, A1 Location in patent:Page/Page column 18; 19
904694-67-3
0 suppliers
inquiry
153800-11-4
68 suppliers
$45.00/10mg