2-Fluoro-5-nitropyridine synthesis
- Product Name:2-Fluoro-5-nitropyridine
- CAS Number:456-24-6
- Molecular formula:C5H3FN2O2
- Molecular Weight:142.09
Synthesis of 5-amino-2-fluoropyridine. A mixture of 5-nitro-2-chloropyridine (2.0 g, 12.6 mmol) and anhydrous potassium fluoride (2.2 g, 38 mmol) in a combination of sulfalone ( 6 mL) and benzene (4 mL) was stirred at RT for 20 min. The benzene was then removed by distillation. The resulting mixture was heated at 150 °C for 12h. The mixture was cooled to RT whereupon water (60 mL) was added. The desired product was separated from the solution via steam distillation. Extraction of the distillate with diethyl ether (2 × 1 0 mL) followed by drying (Na2SO4) and concentration gave the compound. 5-nitro-2-fluoropyridine, water white oil (1.3 g, 73%).
2127-10-8
92 suppliers
$55.00/500mg
456-24-6
226 suppliers
$6.00/1g
Yield:-
Steps:
Multi-step reaction with 2 steps
1: potassium fluoride; chlorine / acetonitrile / 20 h / 0 - 20 °C / Inert atmosphere
2: silver fluoride / neat (no solvent) / 16 h / 60 °C / Inert atmosphere
References:
Kanishchev, Oleksandr S.;Dolbier, William R. [Angewandte Chemie - International Edition,2015,vol. 54,# 1,p. 280 - 284][Angew. Chem.,2015,vol. 127,# 1,p. 282 - 286,5][Angewandte Chemie,2015,vol. 127,# 1,p. 282 - 286,5]
4548-45-2
548 suppliers
$6.00/5g
456-24-6
226 suppliers
$6.00/1g
![[1(2H),2'-Bipyridin]-2-one, 5,5'-dinitro-](/CAS/20210305/GIF/63913-20-2.gif)
372-48-5
392 suppliers
$5.00/5g
456-24-6
226 suppliers
$6.00/1g
4214-76-0
525 suppliers
$6.00/10g
456-24-6
226 suppliers
$6.00/1g
5418-51-9
451 suppliers
$12.72/1gm: