2-Fluoroanisole synthesis
- Product Name:2-Fluoroanisole
- CAS Number:321-28-8
- Molecular formula:C7H7FO
- Molecular Weight:126.13
Yield:321-28-8 98%
Reaction Conditions:
Stage #1:2-fluorophenol with sodium hydride in N,N-dimethyl-formamide at 0 - 20; for 1.5 h;
Stage #2:methyl iodide in N,N-dimethyl-formamide for 16 h;
Steps:
D.D1
D 1. 1 -Fluoro-2-methoxy-benzeneTo a slurry of NaH (28.8g, O.?Omol) in dry DMF (500ml) at 0 0C was added 2-fluoro phenol (5Og, 0.446mol) slowly over a period of 30min and stirred for Ih at room EPO
References:
ASTEX THERAPEUTICS LIMITED;THE INSTITUTE OF CANCER RESEARCH: ROYAL CANCER HOSPITAL;ASTRAZENECA AB WO2006/136829, 2006, A2 Location in patent:Page/Page column 122-123
90-05-1
797 suppliers
$5.00/1g
321-28-8
380 suppliers
$6.00/1g
