2-FLUOROETHYLAMINE HYDROCHLORIDE synthesis
- Product Name:2-FLUOROETHYLAMINE HYDROCHLORIDE
- CAS Number:460-08-2
- Molecular formula:C2H7ClFN
- Molecular Weight:99.54
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Yield:460-08-2 92%
Reaction Conditions:
Stage #1: 2-(2-fluoroethyl)isoindoline-1,3-dionewith hydrazine hydrate in ethanol at 50; for 9 h;
Stage #2: with hydrogenchloride in ethanol;water; pH=5; for 1 h;Reflux;
Steps:
1.2-5.2 (2) Synthesis of 2-fluoroethylamine hydrochloride:
Add 347.7 g (1.8 mol) of 2-fluoroethyl phthalimide intermediate prepared in S1 into a 3L reaction vessel and dissolve it with 2.2L ethanol under mechanical stirring.Then 123.7g (1.98mol) of 80% hydrazine hydrate was added dropwise, and the temperature was raised to 50°C to react for 1h.Then the temperature was raised to reflux for 8h, the pH was adjusted to 5 with hydrochloric acid, refluxed for 1h, filtered,The filtrate is concentrated to dryness, dissolved in a small amount of water, filtered, and the filter cake is rinsed with a small amount of water.The filtrate was concentrated to dryness again, and a small amount of ethanol at about 0°C was added to make a slurry, filtered and dried in vacuum164.7 g (1.656 mol) of white flaky crystal 2-fluoroethylamine hydrochloride was obtained, with a yield of 92%.
References:
CN112645822,2021,A Location in patent:Page/Page column 4-6
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![Borane, difluoro[(2-fluoroethyl)amino]- (7CI,8CI)](/CAS/20210305/GIF/13880-61-0.gif)
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460-08-2
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$7.00/250mg