2-ISONITROSO-4'-(TRIFLUOROMETHOXY)ACETANILIDE 97 synthesis
1synthesis methods
- Product Name:2-ISONITROSO-4'-(TRIFLUOROMETHOXY)ACETANILIDE 97
- CAS Number:175205-25-1
- Molecular formula:C9H7F3N2O3
- Molecular Weight:248.16
Yield:175205-25-1 90%
Reaction Conditions:
Stage #1: 4-(trifluoromethoxy)anilinewith hydrogenchloride;Sodium sulfate [anhydrous] in ethanol;lithium hydroxide monohydrate;
Stage #2: 2,2,2-trichloro-1,1-ethanediol in ethanol;lithium hydroxide monohydrate;
Stage #3: with hydroxyamino hydrochloride in ethanol;lithium hydroxide monohydrate;Reflux;
References:
Mologni, Luca;Rostagno, Roberta;Brussolo, Stefania;Knowles, Phillip P.;Kjaer, Svend;Murray-Rust, Judith;Rosso, Enrico;Zambon, Alfonso;Scapozza, Leonardo;McDonald, Neil Q.;Lucchini, Vittorio;Gambacorti-Passerini, Carlo [Bioorganic and Medicinal Chemistry,2010,vol. 18,# 4,p. 1482 - 1496] Location in patent:experimental part