4-Nitrotoluene-2-sulfonic Acid synthesis
- Product Name:4-Nitrotoluene-2-sulfonic Acid
- CAS Number:121-03-9
- Molecular formula:C7H7NO5S
- Molecular Weight:217.2
Yield:121-03-9 55%
Reaction Conditions:
with pyridine in 1,4-dioxane
Steps:
24 2-Methyl-5-nitro-benzenesulfonic Acid, 2.2-Dimethylpropyl Ester
EXAMPLE 24 2-Methyl-5-nitro-benzenesulfonic Acid, 2.2-Dimethylpropyl Ester Neopentyl alcohol (0.75 g, 8.50 mmol) was added to a solution of commercially available 2-methyl-5-nitro-benzenesulfonyl chloride (1.00 g, 4.20 mmol), pyridine (1.72 mL, 21.2 mmol and anhydrous dioxane (40 mL). A water cooled condenser was attached and the material was heated to reflux. After stirring for two days the mixture was cooled to room temperature and diluted with ethyl acetate (350 mL). The organic layer was washed with water, then 1 N HCl solution, and finally brine. After drying with MgSO4 the solution was concentrated to afford 690 mg of the title compound as a yellow solid.(55%): 1H-NMR (DMSO-6) δ8.57 (d, J=2 Hz, 1H), 8.51 (dd, J=8 Hz, 2 Hz, 1H), 7.85 (d, J=8 Hz, 1H), 3.78 (s, 2H), 2.70 (s, 3H), 0.88 (s, 9H); MS (EI): [M+] 287; Anal. Calc. for C12H17NO5S: C, 50.16; H, 5.96; N, 4.88. Found: C, 49.83; H, 5.69; N, 4.90.
References:
American Home Products Corporation US6355633, 2002, B1
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121-03-9
288 suppliers
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