2-MORPHOLINOBENZALDEHYDE synthesis
- Product Name:2-MORPHOLINOBENZALDEHYDE
- CAS Number:58028-76-5
- Molecular formula:C11H13NO2
- Molecular Weight:191.23
110-91-8
446-52-6
58028-76-5
Example 180: Synthesis of N-(1-methyl-1H-pyrazol-4-yl)-1-(2-morpholinobenzyl)-1H-pyrazolo[3,4-d]pyrimidin-6-amine Step (i): 2-fluorobenzaldehyde (0.5 mL, 4.8 mmol), morpholine (0.6 mL, 1.5 eq.), and potassium carbonate (1.3 g, 2 eq.) were mixed and heated in a microwave reactor at 125 °C for 2.5 hours. Upon completion of the reaction, the solvent was removed by evaporation. The residue was partitioned between water and dichloromethane (DCM) and the aqueous phase was further extracted with DCM. All organic phases were combined, dried over sodium sulfate and subsequently concentrated under vacuum to give 2-morpholino benzaldehyde (0.57 g, 63% yield).
110-91-8
710 suppliers
$9.00/1g
446-52-6
435 suppliers
$6.00/25g
58028-76-5
106 suppliers
$7.00/250mg
Yield:58028-76-5 87%
Reaction Conditions:
with potassium carbonate in N,N-dimethyl-formamide at 150; for 20 h;
References:
D'yachenko;Glukhareva;Nikolaenko;Tkachev;Morzherin [Russian Chemical Bulletin,2004,vol. 53,# 6,p. 1240 - 1247]