2-(PHENOXYMETHYL)BENZALDEHYDE 97 synthesis
- Product Name:2-(PHENOXYMETHYL)BENZALDEHYDE 97
- CAS Number:168551-49-3
- Molecular formula:C14H12O2
- Molecular Weight:212.24
643-79-8
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108-95-2
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168551-49-3
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Yield:168551-49-3 84%
Reaction Conditions:
with triethyl phosphite in dichloromethane at 20; for 4 h;Reagent/catalyst;
Steps:
1-2
In a 25 mL round bottom flask, 5.0 mL of dichloromethane, 0.5 mmol of o-phthalaldehyde, 0.55 mmol of phenol and 0.55 mmol of triethyl phosphite were sequentially added, and the resulting reaction mixture was stirred at room temperature for 4 hours. After the reaction is completed, the solvent is removed by rotary evaporation, and the crude product is purified by 200-300 mesh silica gel column chromatography. The eluent is a mixed solvent of petroleum ether and ethyl acetate with a boiling range of 60-90 degrees Celsius, and the volume ratio is 40:l-30 :1 to obtain a colorless oily liquid with a yield of 84%. The preparation amount of the benzyl aryl ether target compound I and the volume of the reaction vessel can be expanded or reduced according to the corresponding ratio. The chemical structure and physical and chemical parameters of the target compound I are shown in Table 1.
References:
CN113321575,2021,A Location in patent:Paragraph 0044-0050
2591-86-8
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94191-73-8
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168551-49-3
31 suppliers
$45.00/10mg