2-Thiobarbituric acid synthesis
- Product Name:2-Thiobarbituric acid
- CAS Number:504-17-6
- Molecular formula:C4H4N2O2S
- Molecular Weight:144.15
Yield:504-17-6 80%
Reaction Conditions:
with sodium in ethanol; for 6 h;Reflux;
Steps:
Synthesis of Thiobarbituric acid
About 6g (0.25mol) of sodium metal isdissolved in 200 mL of ethanol. To this solution 15g(0.25mol) of thiourea and 40 mL of diethyl malonateis added. The reaction mixture is reuxed for 6 hrsin an oil bath and then vacuum distillated to makeethanol recovery. The clear solution thus obtained isfltered, cooled in ice bath overnight and the resultingsolution is acidifed with HCl. The crude productobtained is collected, washed with 50 mL water anddried in oven at 105°C-110C for nearly 4 hrs. Theobtained compound Thiobarbituric acid (TBA) ispurifed by recrystallization with ethanol and theirrespective melting point is about 243C with 80%yield is obtained.
References:
Kalaiarasi;Manivarman [Oriental Journal of Chemistry,2017,vol. 33,# 1,p. 304 - 317]
1004-40-6
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$19.00/5g
7664-93-9
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$23.30/1090731000
504-17-6
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$10.00/5g
1004-39-3
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$15.00/1g
7664-93-9
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$23.30/1090731000
504-17-6
408 suppliers
$10.00/5g