2-(Trimethylsilyl)ethoxymethyl chloride synthesis
- Product Name:2-(Trimethylsilyl)ethoxymethyl chloride
- CAS Number:76513-69-4
- Molecular formula:C6H15ClOSi
- Molecular Weight:166.72
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76513-69-4
Step 4: Take a small amount of intermediate reagent and place it in the reactor, heat to reflux and maintain reflux for 4 hours. After completion of the reaction, cool to 20°C and slowly add trimethylchlorosilane dropwise. During the dropwise addition, the temperature of the solution was gradually increased. Step 5: At the end of the reaction, desorption operation was carried out, controlling the temperature of the depressurized reactor not to exceed 40°C. The residual system residue was dissolved to form a viscous substance, and ethanol was added slowly until no bubbles were generated, and the waste was disposed of. Finally, the solution obtained by desolventization is distilled to collect 2-(trimethylsilyl)ethoxymethyl chloride with a purity of more than 99%.
Yield:76513-69-4 99%
Reaction Conditions:
Stage #1: 1-bromo-2-(chloromethoxy)ethanewith magnesium for 4 h;Reflux;
Stage #2: chloro-trimethyl-silane at 20;Reagent/catalyst;
Steps:
1
The fourth step to take a small amount of intermediates made of reagents,After heating, the system slowly heated up to reflux, refluxed for 4 hours, cooled to 20 degrees, slowly dropping trimethylchlorosilane; the temperature of the solution was increased gradually; Fifth step to be the end of the reaction temperature of the end of desorption, decompression reactor temperature control of not more than 40 degrees, after the dissolution of the residual system residue residue for the viscous material, slowly adding alcohol to no bubbles, as waste Treatment, the solution obtained by desolvation, distillation of more than 99% to 2 _ (trimethylsilyl) ethoxymethyl chloride.
References:
CN103408576,2016,B Location in patent:Paragraph 0020; 0021; 0025
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