ETHYL 6-METHYL-4-(4-METHYLPHENYL)-2-OXO-1,2,3,4-TETRAHYDRO-5-PYRIMIDINECARBOXYLATE synthesis
- Product Name:ETHYL 6-METHYL-4-(4-METHYLPHENYL)-2-OXO-1,2,3,4-TETRAHYDRO-5-PYRIMIDINECARBOXYLATE
- CAS Number:299949-24-9
- Molecular formula:C15H18N2O3
- Molecular Weight:274.32
104-87-0
520 suppliers
$6.00/25g
141-97-9
842 suppliers
$5.00/25g
57-13-6
805 suppliers
$5.00/5g
299949-24-9
19 suppliers
$28.60/25MG
Yield:299949-24-9 100%
Reaction Conditions:
with copper(II) bis(trifluoromethanesulfonate) in ethanol at 100; for 1 h;Microwave irradiation;Inert atmosphere;Biginelli reaction;
Steps:
Synthesis of dihydropyrimidinones
General procedure: Aldehyde (1.0 mmol), ethyl acetoacetate (1.0 mmol), urea (1.5 mmol), Cu(OTf)2 (0.02 mmol), and EtOH (2 mL) were added to a microwave vial equipped with a magnetic stir bar. The reaction vessel was sealed and irradiated in a microwave reactor (CEM Discover system) at a temperature of 100 °C for 1 h at a maximum power of 200 W. The reaction mixture was cooled to room temperature overnight and the resulting precipitate was filtered and washed with H2O and hexane. The identity and purity of the products were confirmed by TLC, high-resolution mass spectrometry, IR and 1H and 13C NMR spectroscopy
References:
Pasunooti, Kalyan Kumar;Chai, Hua;Jensen, Chantel Nixon;Gorityala, Bala Kishan;Wang, Siming;Liu, Xue-Wei [Tetrahedron Letters,2011,vol. 52,# 1,p. 80 - 84] Location in patent:supporting information; experimental part
589-18-4
316 suppliers
$5.00/5g
141-97-9
842 suppliers
$5.00/25g
57-13-6
805 suppliers
$5.00/5g
299949-24-9
19 suppliers
$28.60/25MG
104-87-0
520 suppliers
$6.00/25g
1723-25-7
25 suppliers
inquiry
57-13-6
805 suppliers
$5.00/5g
299949-24-9
19 suppliers
$28.60/25MG
2929-93-3
0 suppliers
inquiry
141-97-9
842 suppliers
$5.00/25g
57-13-6
805 suppliers
$5.00/5g
299949-24-9
19 suppliers
$28.60/25MG
141-97-9
842 suppliers
$5.00/25g
104-82-5
389 suppliers
$10.00/5mL
57-13-6
805 suppliers
$5.00/5g
299949-24-9
19 suppliers
$28.60/25MG