4-(5-BROMO-1,3-DIOXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)BUTANOIC ACID synthesis
- Product Name:4-(5-BROMO-1,3-DIOXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)BUTANOIC ACID
- CAS Number:299964-12-8
- Molecular formula:C12H10BrNO4
- Molecular Weight:312.12
86-90-8
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56-12-2
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299964-12-8
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Yield:299964-12-8 96.7%
Reaction Conditions:
with acetic acid at 100; for 3 h;
Steps:
5 Example 5
4-Bromophthalic anhydride (450 mg, 2.0 mmol) and 4-aminobutyric acid (206 mg, 2.0 mmol) were added to glacial acetic acid (10 mL) and heated to 100 ° C for 3 h.The reaction was quenched with water (10 mL), and the pH of the solution was adjusted by NaOH solution (0.1 mol/L).It is 6-8. Dichloromethane extraction (10 mL × 3), washed with saturated NaHCO3 solution, washed with waterAfter drying, it has a yellow solid of 600 mg.LC-MS and 1H-NMR confirmed the expected intermediate compound in a yield of 96.7%.
References:
CN109867661,2019,A Location in patent:Paragraph 0154; 0155
6941-75-9
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$5.00/1g
56-12-2
966 suppliers
$5.00/100mg
299964-12-8
20 suppliers
$45.00/50mg