3-(3-fluoro-4-methoxyphenyl)propionic acid synthesis
- Product Name:3-(3-fluoro-4-methoxyphenyl)propionic acid
- CAS Number:69888-90-0
- Molecular formula:C10H11FO3
- Molecular Weight:198.19
110-89-4
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$15.96/100ML
351-54-2
250 suppliers
$10.00/1g
69888-90-0
50 suppliers
$27.00/250mg
Yield:69888-90-0 66%
Reaction Conditions:
with pyridine;malonic acid;palladium-carbon in water;acetic acid;
Steps:
R.8 3-(3-Fluoro-4-methoxyphenyl)propionic Acid
Reference Example 8 3-(3-Fluoro-4-methoxyphenyl)propionic Acid Malonic acid (7.5 g, 72.1 mmols) and piperidine (0.84 g, 9.83 mmols) were added to a pyridine (20 ml) solution of 3-fluoro-4-methoxybenzaldehyde (10.1 g, 65.5 mmols), and the mixture was stirred under heat at 120° C. for 7 hours. The reaction mixture was poured into water containing ice, and the powder that precipitated was taken out through filtration. The powder was dried and dissolved in acetic acid (300 ml) without being further purified. To this was added 5% palladium-carbon (3 g, containing 50% water), and the mixture was stirred in a hydrogen atmosphere at room temperature for 2 hours. The reaction mixture was filtered, and the filtrate was concentrated under reduced pressure to obtain 8.54 g (yield: 66%) of the target compound. m.p.: 114-117° C.; NMR (CDCl3) δ: 2.65 (2H, t, J=7.5 Hz), 2.89 (2H, t, J=7.5 Hz), 3.87 (3H, s), 6.80-7.00 (3H, m), hidden (1H)
References:
US6034239,2000,A
2033-24-1
654 suppliers
$6.00/25g
351-54-2
250 suppliers
$10.00/1g
69888-90-0
50 suppliers
$27.00/250mg
141-82-2
791 suppliers
$5.00/25g
351-54-2
250 suppliers
$10.00/1g
69888-90-0
50 suppliers
$27.00/250mg
713-85-9
18 suppliers
$60.00/100mg
69888-90-0
50 suppliers
$27.00/250mg
351-54-2
250 suppliers
$10.00/1g
69888-90-0
50 suppliers
$27.00/250mg